Article Abstract

Association of two polymorphisms rs3740199 and rs1871054 at ADAM12 with susceptibility of knee osteoarthritis: a systematic review and meta-analysis

Authors: Wenxiang Chen, Yiying Wang, Xuesheng Jiang


Background: Osteoarthritis (OA) is the most common joint disease that mainly influences the knees, hips, hands and spine. However, the pathogenesis of knee OA remains poorly understood. A number of studies have explored the association between ADAM12 polymorphisms and the risk of knee OA in different populations. We aimed to systematically review those observational studies, taking into account the variable quality of studies.
Methods: We carried out a systematic review and meta-analysis of these studies based on ADAM12 rs3740199 and rs1871054 genotypes. Four comparisons involving 2 Chinese, 1 Korean and 1 Thai population of 1,241 knee OA patients and 2,316 controls were included in our study.
Results: For the SNP rs1871054, the C allele was associated with an increased risk of knee OA in terms of the frequency of allele comparison. For a dominant model of the C allele, the CT + CC genotypes were associated with the risk for knee OA. The CC homozygote genotype was also associated with increased susceptibility to knee OA. However, the ADAM12 rs3740199 polymorphism was suggested not to be related to knee OA susceptibility in all populations.
Conclusions: The present results suggested that there existed a positive relationship between the ADAM12 rs1871054 polymorphisms with the susceptibility of knee OA, while the ADAM12 rs3740199 was not observed to be associated with the risk of knee OA.