Musculoskeletal (MSK) imaging has undergone a major transformation over the past five decades. Advancements in orthopaedic surgery and arthroscopy have developed in unison with imaging techniques, which has led to improvements in clinical diagnosis, therapeutic interventions and patient prognostication.
With recent major developments of magnetic resonance imaging (MRI), attention has turned to the unique capability of defining bone morphology and soft tissue abnormalities. Additionally, the development of state-of-the-art quantitative MRI techniques has allowed for the depiction of early stage cartilage lesions (1). However, MRI is still limited in its ability to provide static morphological diagnosis. In the future, we will likely see all-in-one patient-centric examinations based on MRI, which can provide valuable information on joint morphology, biochemical function and dynamic “in vivo” assessment.
Conventional radiography (XR) remains the cornerstone of hip imaging (2), and continues to have a role in screening, diagnosis and post-operative surveillance. The advent of computed tomography (CT), represented a transformation in clinical practice from XR to cross-sectional imaging. Initially, only low-quality axial two-dimensional images were available and examination times were even longer than current MRI acquisition times. Only with the establishment of multiplanar reconstructions based on 3D data sets was the use of CT in MSK imaging transformed (3), allowing for accurate and improved surgical planning (Table 1).
MRI allows for a more comprehensive analysis of the articular cartilage, capsulolabral tissue, soft-tissue and osseous structures (14). Thirty years ago, MRI examinations were technically difficult and resulted in low resolution images. The development of MR arthrography (MRA) had a major impact on treatment decisions, particularly in the evaluation of cartilage and labral integrity (2). In the mid-1990s MRA was the examination of choice for the evaluation of labral disruption, and remains the imaging gold-standard for patients with femoroacetabular impingement (FAI) (15).
The hip joint has gained particular attention in the last decade in parallel with significant advances in MSK imaging. Ganz developed a revolutionary technique that allowed for safe dislocation of the hip and direct visualization of the joint, which provided fundamental insights into the pathogenesis of early osteoarthritis (OA) (3,13). New biomechanical concepts were recognized such as the depiction of FAI as a major cause of secondary OA in non-dysplastic hips (14-18).
Crucial questions still remain to be answered. For instance:
- What morphological factors, beside cam-type FAI and dysplasia contribute to hip OA (19)?
- During disease progression, what is the exact discriminative point when cartilage damage becomes irreversible (20)?
- Why are some patients with FAI morphology asymptomatic and never develop OA (21-23)?
Accurately determining the amount of articular cartilage injury is important as it has a direct impact on the clinical decision-making between hip preservation surgery and total hip replacement (24). The workup of the young patient with hip pain generally follows specific algorithms (25) (Figures 1,2). The primary goals of diagnostic imaging are to accurately identify osseous morphology and characterize the amount of chondrolabral damage. However, it is important to understand the limitations and strengths of each imaging modality, as for example, both XR and CT lack accuracy for assessing articular cartilage pathology (2), whereas specific MRI sequences and advanced technologies can be useful (26).
New technical and imaging innovations are presently available in routine clinical setting, bringing important implications to the study of the young hip (21). The diagnostic performance of these techniques may therefore improve the ability to predict an individual patient-specific outcome (2,22).
Algorithm for evaluation of FAI used at Hospital da Luz in Lisbon. First, the diagnosis of FAI is suspected based on patient history and clinical findings. Next, the hip is assessed on an anteroposterior pelvic radiograph (acetabulum and pincer morphology) and on a 45° Dunn view. Using MRI, the morphology of the femur is assessed (cam deformities, femoral torsion) and damage to the cartilage and labrum is evaluated. Lastly, all data are combined to reach a diagnosis, define appropriate course of treatment and follow-up.
Schematic figure representing proposed complete MRI protocol for the assessment of the young hip. 2D sequences with radial imaging are used for the assessment of morphology and pathology. Version assessment of the femoral neck is performed. 3D sequences to allow for correction of pelvic tilting, 3D modelling, 3D printing and virtual ROM simulations. Finally, a sequence that allows for cartilage biochemical mapping.
After history and clinical examination, XR is useful to assess for OA, including evaluation of bone morphology, joint space width as well as to exclude other hip pathology (23). XR should include a standing anteroposterior (AP) view of the pelvis, and a lateral view of the affected hip. Nonetheless the utility and accuracy of the various types of radiographs remains controversial (25,27).
Ultrasound, arthrography and CT
Conventional arthrography is seldomly performed as it has been replaced by MRA. However, the origin of the referred hip pain might still be confirmed by intra-articular anesthetic injection (28). Ultrasound is not routinely used in the workup of FAI, although ultrasound-guided injection procedures can be helpful to exclude pain derived from periarticular structures such as trochanteric pathology, iliopsoas bursitis and other myotendinous elements (29). CT can be helpful in the characterization of fractures and unusual bony anatomy. Further, it is helpful to evaluate bony morphology of the pelvis, version, the anterior inferior iliac spine and extra-articular causes of impingement, as well as, building 3D models (30-32). Regarding FAI, pincer-type morphology is currently well addressed with standard pelvic XR (25), while for cam morphology, CT or MRI can offer a clear advantage since the complexity of the three-dimensional femoral shape can be thoroughly evaluated (33). Furthermore, measuring femoral version is only feasible with cross-sectional imaging (25).
Magnetic resonance imaging
MRI is an all-in-one imaging method as it depicts joint and periarticular pathology, including stress fractures, myotendinous injuries, bursitis and signs of ischiofemoral impingement (26). MRI can accurately assess bone morphology associated with FAI syndrome and detect chondrolabral damage. While conventional MRI can only detect macroscopic chondral damage (34), the presence of subchondral edema and cystic changes, have been shown to be indirect signs of advanced cartilage changes in the hip joint at the time of arthroscopy (35).
- Conventional MRI;
- Magnetic resonance arthrography (direct/indirect; with or without traction);
- Quantitative biochemical MRI: T2/T2* mapping, delayed gadolinium-enhanced of cartilage (dGEMRIC) and T1rho (T1ρ).
- High-resolution 3D sequences for imaging of cartilage (23);
- Biochemical imaging of cartilage;
- 7.0 Tesla MRI (39);
- Imaging of metal prosthetics with novel MRI pulse sequences (22).
New quantitative MRI imaging is encouraging for early detection of chondral and labrum injuries (40), as it probes changes in cartilage properties and biochemical composition, which represents an early stage of the degenerative cascade (41).
- Time: maintain patient throughput with short examination times (around 30 minutes);
- Magnet: 3.0Tesla MRI has been widely adopted for hip evaluation. The theoretical doubling of signal-to-noise ratio can be used to obtain high-resolution (hR) imaging and/or shorter scan acquisition times;
- Coils: dedicated hip coils for optimal image quality (44). Improved coil geometry will further improve image quality;
- Advanced morphological sequences (37):
- Implementation of parallel imaging allowing scan time to be accelerated;
- Compressed sensing;
- Isotropic MR images allowing for multiplanar reformats and 3D imaging.
MRA can be performed by introduction of contrast material either (I) intra-articularly, as in direct MRA (dirMRA) or (II) intravenously, as in indirect MRA (indMRA) (45).
A detailed and comprehensive protocol for dirMRA should be strictly followed to achieve maximum quality (Figures 2-6). MRA of the hip plays a major role in:
- Diagnosing internal derangements of the joint (46);
- Evaluating symptomatic improvement following administration of anesthetic, helpful to confirm that symptoms and joint changes are related.
Several studies have compared the performance of these different protocols with variably reported accuracies (47-49). Previously, MRA has shown to be more accurate in detecting minor acetabular cartilage defects than non-contrast MRI (50,51). Diagnostic test accuracy was shown to be better for dirMRA when compared with conventional MRI for detection of labral and cartilage injury, in specific chondral lesions. Concerning indMRA, good results were also obtained, although more studies are needed to fully assess its accuracy (52). In patients with suspected FAI, MRA may still be considered the gold standard of imaging for the evaluation of the chondrolabral injury (25,49,53).
MR arthrography with leg traction
The rationale behind traction MRA (traMRA) is centered on the separation of the acetabular and femoral surfaces allowing a better assessment of the chondrolabral interface and central compartment (54,55). Recently, a study correlating traMRA with arthroscopy assessed the utility of this technique for the diagnosis of chondrolabral damage (55). Traction was well tolerated by most patients and consistently achieved separation of cartilage layers, enabling accurate detection of chondral and labral lesions (55).
Procedure: prior to the application of traction with the hip slightly flexed, a conventional arthrography injection (10–27 mL) is performed and MR-compatible traction devices are routinely used for continuous traction during the examination. Traction devices consist of a weight connected to a pulley system, a cable or rope connected to the leg either with an ankle brace or with adhesive straps for skin traction. The amount of traction varies between 6 and 23 kg for a period ranging between 3 and 19 min among different studies (51,54,55).
Schmaranzer et al. (55) reported detection of acetabular/femoral chondral injury with a sensitivity of 85–88%/81–86% and specificity of 78–96%/91–94%, respectively (Table 2). The combination of contrast agent and additional space from distraction allows for improved visualization of the cartilage surfaces of the femoral head and acetabulum as distinct entities.
Advanced cartilage imaging
Improved evaluation of articular cartilage status is imperative to allow both assessment of patients who may benefit from FAI surgery, as well as, long-term evaluation of clinical outcomes (26). Recognition of pre-existing degenerative changes at an early stage is therefore crucial. Although large defects can be confidently detected by conventional MRI, morphologic sequences lack crucial (quantitative) information on the pathophysiology of cartilage degeneration (36). Prior to structural damage of the cartilage, early changes can be evaluated using functional MRI techniques (1). This field remains an ongoing subject of research and future developments are necessary to allow its widespread use (1). Currently the main limitations include the narrow applicability of normative threshold standards (as they are dependent on multiple factors) and current indefinite clinical correlation. Challenges in quantitative imaging (17,23,41,58) presently include:
- Hardware related:
- Need for dedicated cartilage-specific sequences and high-MR field strengths;
- High signal-to-noise (SNR) ratio and high-spatial resolution;
- Technical variations (changes in acquisition parameters can lead to limited comparability).
- Anatomy related:
- Hip joint cartilage (deep location, thickness and its spherical shape);
- Hip susceptibility to artifacts and volume averaging;
- Mapping values represent the sum of the signal of joint fluid and both chondral surfaces;
- Standard regional/sectorial differences in the biochemical composition of hip cartilage.
- Patient related:
- Cartilage loading (has an influence on the extracellular matrix). Current recommendation is that this technique should be performed in the unloaded state at the end of the MR scan;
- Inter-subject anatomic variations (can lead to misinterpretations with added limited comparability; patient-driven normalization can compensate for deviations caused by technical changes and variations related to age and individual cartilage configuration).
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
Glycosaminoglycan (GAG) are negatively charged polysaccharides (consist of NH and OH groups) that highly attract water and serve to resist compressive forces. High contents are found in the extracellular matrix of healthy cartilage (1). The dGEMRIC is used for assessing typical features of early-onset OA, namely GAG loss and collagen breakdown (41). It is based on the use of a contrast agent named gadopentetate dimeglumine [Gd(DTPA)2]. Gd(DTPA)2– is an anionic molecule and is negatively charged. In the case of depletion of GAGs due to arthritis, these GAG’s are replaced by Gd(DTPA)2– within the cartilage if given time. Consequently, the measurable Gd(DTPA)2– concentration is relatively low in native cartilage and relatively high in case of arthritis. The distribution of Gd(DTPA)2– in the cartilage can be measured by a T1 weighted sequence. By measuring the spatial variations between Gd(DTPA)2– and GAGs, the quality of cartilage can be determined (75,76).
This technique can either be used with direct intra-articular or intravenous injection of a contrast agent (75), and a time delay separating contrast agent administration and image acquisition is used (intravenous: 30–90 min; intra-articular: 15–30 min) (76). The most widely used protocol of Burstein recommends 10–20 minutes of exercise (e.g., walking, climbing stairs, and cycling) immediately after the contrast administration. No exercise is recommended after intra-articular based protocol. It has been suggested that isolated T1Gd assessment of the hip joint cartilage is sufficient for the evaluation without the need for time consuming pre-contrast imaging (except in the setting of post-operative cartilage repair) (77). Baseline dGEMRIC was shown to be able to predict the development of radiographic OA (40). Similarly, the size and position of cam morphology determined the severity and location of progressive cartilage damage, supporting the biomechanical etiology of FAI (18,78).
T2 and T2* mapping (Figures 7,8)
T2/T2* mapping have been shown to correlate with chondral matrix hydration and collagen integrity (1). Each tissue has a similar transverse relaxation time (T2) at a specified MR strength. Relaxation times are correlated to the speed by which nuclei lose phase after magnetic excitation. An additional de-phasing effect comes into play if gradient-echo MRI is performed, referred to as T2* mapping. T2 mapping is a well proven imaging modality (79). However, the orientation of collagen fibres influences the estimation of T2 relaxation values and reduces the accuracy of T2 mapping in certain regions of articular cartilage (magic angle effect). Due to the magic angle effect, T2 values of cartilage are influenced by its orientation relative to the static magnetic field (B0). Secondly, the acquisition times are relatively long. Thirdly, T2 mapping appears less sensitive for detecting early stages of cartilage lesions (80). T2* mapping has shorter acquisition times and higher resolution compared to T2 mapping although it is more prone to magic angle effects and is more susceptible to artifact (70).
T1ρ (T1 rho)
Similar to dGEMRIC, T1rho (T1ρ) relaxation time mapping is sensitive to the GAG content of hyaline cartilage. In a T1ρ sequence the spins in the direction of the B0 magnetization are first flipped into the transverse plane by a 90-degree radiofrequency (RF) pulse. A second RF pulse, better known as spin-lock pulse, is applied parallel to the magnetization vector. This spin-locked magnetization will relax with a time constant T1ρ and is dependent on the frequency and duration of the spin-lock pulse (TSL). The spin-lock pulse is applied with variable TSLs, at least two, at certain intervals which are also depended on the spin-lock frequency.
T1ρ—like T2 mapping—is founded on the motion of water molecules. T1ρ is widely considered to be sensitive to the protons of hydrogen molecules attached to proteoglycans of cartilage due to the second spin-lock pulse (64). Nevertheless, correlation with other factors, such as extracellular matrix, collagen content and collagen orientation were found too. The general consensus is that T1ρ may provide an imaging biomarker for the detection of cartilage degradation, based on the tissue’s macromolecular content (41). In the FAI setting, it has been shown that early femoral and acetabular chondral changes can be detected before macroscopic lesions are apparent, and displays differences in distribution patterns across the deeper and superficial cartilage layers (64,81).
gagCEST has been used in the knee joint and conceptually is the only technique that directly measures GAG cartilage content (82). It is based on an asymmetry in the z-spectrum of cartilage created by hydroxyl groups in the GAG molecule. The application of this method in the hip has not yet been demonstrated.
Sodium (23Na) cartilage imaging can be also performed in this setting. The rationale behind its use centers on the negatively charged GAG molecules in the cartilage binding of positively charged Na+ maintaining the electroneutrality of the extracellular matrix (83). Na molecules conceptually distribute in proportion to the GAG molecules in degenerated articular cartilage. As such, proteoglycan cartilage loss caused by cartilage degeneration can be visualized (84). 3D-Isotropic MRI mapping sodium using a 7.0 Tesla system was used for the assessment of the knee, showing promise as a feasible alternative for evaluating OA (39). Limitations of sodium mapping include the need for a high-field MRI and dedicated hardware as well as anatomical constraints due to the deep location of the hip chondral surfaces.
Near future perspectives
Knowledge of biomechanics and physiopathology of the hip evolves in parallel with the need for non-invasive strategies to further assess the joint. As such, it is imperative for simultaneous advances in both static and dynamic automated imaging techniques. Currently, the acquisition of XR and MRA are the cornerstone of hip imaging. Computer-assisted (CompAssist) techniques have been based on data derived from isotropic CT images, while some studies based segmentation of those datasets on alternative tools such as MRI (85,86). However, MRI-based automated segmentation (AutSeg) has not yet reached the clinical standard due to relatively low contrast differences between bone and soft tissues (85).
- Tools for accurate diagnosis and cartilage mapping;
- Pre-operative treatment planning and virtual treatment performance;
- AutSeg algorithms as well as intra-operative non-invasive registration methods such as statistical shape models (SM);
- Intra-operative navigation (OpNav).
Developing OpNav tools to execute the pre-operative plan is currently a focus of expanding research, which has already seen clinical applications in hip and knee arthroplasty. These advances will hopefully lead to improved accuracy of intra-operative decision-making for both open and arthroscopic FAI procedures (89-91).
3D modeling (Figure 9)
Traditionally, surgeons have relied on 2D imaging to pre-operatively assess the hip, before evaluating areas of impingement by means of intra-operative dynamic visualization and fluoroscopy. However, subject-tailored surgical planning is developing on the basis of 3D hip modeling (92).
Patients with FAI have abnormal complex 3D bone and soft-tissues morphology. As such, routine 3D modeling may provide the surgeon a better understanding of the abnormal bony pathomorphology that would otherwise be difficult to visualize on 2D images. Models based on biplanar (92), 3D CT (30) or MRI (93) data sets (Figure 9) have been used to simulate specific individual bone morphology, define impingement-free range of motion (ROM), and to perform virtual functional analysis with different degrees of function (88). However, further clinical applicability and validation of these models for clinical diagnostics is still needed.
Automated image analysis
Most of the previous AutSeg work has been performed using XR (92) or CT (94-96). Advances in image processing have helped automate measurements, as well as, bone segmentation, thereby improving objectivity and reproducibility. Adding 3D anatomical information to the AutSeg (97) may be useful in reaching better imaging results that are less dependent on other parameters such as patient positioning.
MR imaging enables noninvasive, all-in-one, 3D assessment of the joint structure including biochemical changes with no ionizing radiation and optimal soft tissue contrast. Automated analysis using MR image sets (Figure 10) includes (85):
- An SM-based algorithm allows building 3D femoral and acetabular reconstructions;
- A coordinate system of the joint is generated to build a 2D shape map to project femoral head sphericity for calculation of specific parameters (for instance alpha angles);
- Automatically reformatted images using the constructed coordinate system;
- Automated evaluation of desired parameters according to specified algorithm (Figure 10).
- Allows for large-scale morphometric and clinical MR investigations of the hip region;
- High reliability and reproducibility;
- Improved analyses of cam-type morphology.
Imaging-based dynamic ROM simulations and virtual surgery
3D data sets of volumetric imaging bear high potential for the dynamic assessment of FAI allowing to perform pre-operative simulation of ROM, collision detection and accurate visualization of impingement areas. In addition to virtual 3D reconstruction of the hip joint, dynamic manipulation of the image may be useful to the surgeon, when pre-operatively assessing the deformity and planning for surgical correction (90) (Figure 11).
- “HipMotion” (86) constructs 3D representations of the femur and pelvis from CT. In addition, the model can be manipulated by the user, and pre-operative virtual ROM for patients with FAI can be calculated based on contact or interference occurring at the point of impingement.
- 3D software package Mimics (94) (Materialise, NV, Heverlee, Belgium). Automated morphologic analysis of the cam lesion can be conducted by MATLAB (Math Works, Natick, MA) and used to measure the clinical ROM of the hip joint. Measured motions are imposed on the 3D reconstructed anatomy, and the size and location of the abutting portion of the cam lesion are defined for each motion.
- “Dionics PLAN Hip Impingement Planning System” (Smith & Nephew, Andover, MA) is a tool used to analyze patient-specific CT images. After automatic 3D rendering of the hip, dynamic ROM can be analyzed and areas of bony impingement defined on both the proximal femur and acetabular rim/pelvis. In addition, virtual surgical correction can be performed and dynamic impingement-free ROM reassessed. This tool also provides a platform for intra-operative assistance by performing virtual correction and creating an in vivo comparative virtual fluoroscopic image.
- Hip Analysis/semi-AutSeg using “ArticulisTM” (Clinical Graphics, The Netherlands) has been validated and tested for reliability (30). Multiple studies have successfully used this software for research and clinical purposes in asymptomatic and symptomatic populations from CT and MRI data sets (22,23,99,100).
3D imaging and computer navigation could play a major role in the planning of HPS. Furthermore, these advances could improve patient outcomes and lessen intra-operative and postoperative complications, such as under resection and over resection (88). For instance, it has been used in different hip pathologies, such has:
- FAI (88): a modified version of BrainLAB Hip-CT, which has primarily been used to assist with total hip arthroplasty (91) has been applied to arthroscopic FAI surgery. A C-arm adapter (Fluoro 3D, Vector Vision) can be used to synchronize the 3D CT dataset with intra-operative fluoroscopy allowing real-time feedback of surgical instrument placement in relation to the FHN (101). Planning and conduction of navigated osteochondroplasty using a surgical milling device was feasible and accurate (91).
- PAO (89): Pflugi et al. used two measurement units attached to the pelvis and peri-acetabular fragment. Registration of the patient was obtained with a pre-operatively acquired SM (considering the anterior pelvic plane) and a specific device used to include that orientation in the reference coordinate system. After registration, the two sensors are applied and orientation is displayed. A patient-SM generated from a pre-operatively acquired 3D data-set is used to monitor in real-time the re-orientation of the peri-acetabular fragment to improve femoral coverage.
Real-time functional imaging
Biomechanical knowledge on hip impingement has been limited from research using intra-operative observation (13) and computer models (86,102). Real-time in vivo impingement under conditions of physiologic joint loading would be ideal and hopefully lead to an improved understanding of which hips and morphologies become symptomatic.
Open MRI with ROM testing in vivo has significant advantages compared to computer simulations, image-based model tracking, intra-operative observation, and ex vivo studies as it permits (103):
- Assessment of impingement in hips during functional postures;
- Evaluating the effect of posture and cam/pincer morphology size on clinically meaningful impingement;
- Visualization of differences in cam morphology “behavior” between symptomatic and non-symptomatic cohorts.
Having virtual simulations as a starting point, one can easily appreciate the advantage of combined in vivo imaging and real time functional analysis.
A long way was seen from radiographs to 3D printing (3Dpr), but undoubtedly computerization of radiology and orthopedics is an inescapable fact. 3D imaging and printing might be a step forward for patient-centric tailored approach, from individual anatomy to treatment planning and building specific hardware needed for each patient (99). 3Dpr might be applied in subject-specific tools and surgical device building (100,104), as well as, in complex clinical settings such as pelvic osteotomies (105).
A combination of 3Dpr and CompAssist virtual surgical planning has also been used for pre-operative planning of acetabular fracture reduction (106). The authors stated that 3Dpr technology combined with virtual surgery for acetabular fractures is feasible, accurate, and effective leading to improved patient-specific pre-operative planning and outcome of real surgery.
Future trends in MSK radiology
MRI in 2050
In brief, the future of MRI will include comprehensive 3D joint imaging, done within fractions of the time currently spent and multiparametric in nature, allowing for automated biochemical cartilage analysis. Undoubtedly MRI trends include:
- Field strengths greater than 3.0 Tesla will be the new standard;
- 3D MRI acquisitions with potential for secondary multiplanar reconstructions performed in any desired sequence weighting;
- hR non-contrast imaging will replace MRA, with improved hR 3D cartilage assessment;
- Implementation of quantitative imaging biomarkers in clinical routine imaging;
- Semiautomated or fully automated diagnostic examinations (with the aid of artificial intelligence algorithms to diagnose and automatically quantify specific parameters).
Magnetic resonance fingerprinting (MRF) (107)
MRF uses a pseudorandomized acquisition that prompts the characteristics from different tissues to have a unique signal or “fingerprint” that is dependent of the unique multi-dimensional material properties under analysis. This technique permits a noninvasive quantification of multiple properties of a material or tissue simultaneously through a new approach to data acquisition, post-processing and visualization. These can then be translated into quantitative maps of the MR parameters of interest. This technique would be useful to:
- Provide a novel approach to analyze, quantify and diagnose simple and complex changes that can represent disease surrogates on early/preventable disease;
- Accurately identify the presence of targeted molecules/tissue-specific material, which will increase the diagnostic and prognostic capability of MRI;
- Substantially decrease measurement errors and improve accuracy when coupled with a specific pattern recognition algorithm.
Big data and artificial intelligence
Understanding the advantages and limitations associated with large databases, particularly in the era of value-based health care is paramount. The implementation of standardized national orthopedic registries in conjunction with readily programmable and adaptable programs tailored to radiologists and orthopedic surgeons will ultimately improve patient outcomes while minimizing the economic burden (108,109).
One promising new technology with the potential to launch the next stage of progress in medical image is artificial intelligence (AI), which is the science of engineering intelligent machines and computer programs. Machine learning (ML) derives from AI and is defined as a set of methods that automatically detect patterns in data, and then utilize those patterns to predict future data or enable decision making under uncertain conditions (110). Applications in medical imaging include (111) (I) automatic labeling and captioning; (II) image segmentation and registration; (III) computer-aided detection and diagnosis; (IV) acting as a reading assistant and automatic dictation; (V) integration with healthcare big data.
Personalized medicine and biobanks
Personalized medicine will transform radiology and the health system within the next 50 years. The original concept of precision medicine involves the prevention and implementation of treatment strategies that consider individual variability by assessing large sets of data, including patient information, medical imaging, and genomic sequences (112). Patient-based imaging data will be implemented and cross-linked to population based–data already acquired in biobanks. These biological databanks are designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. They are already well underway and established as a comprehensive population-based health knowledge (112).
Technological innovation was essential for the recent transformation of MSK imaging. State-of-the-art contemporary joint imaging has allowed for improved diagnostic accuracy of most conditions that affect the hip and surrounding structures. Imaging the hip in the future will permit an ultra-fast, near perfect, noninvasive automated quantification of clinically relevant bone and soft tissue pathology through data acquisition, post-processing and visualization. Conceptually, this will involve a personalized approach and population-specific matching to standardize data from healthy and diseased individuals.
The authors would like to thank José Roquette, João Sá, Isabel Vaz and Pedro Patrício for their continuing and enthusiastic support of clinical research at Hospital da Luz.
Conflicts of Interest: The authors have no conflicts of interest to declare.
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Cite this article as: Mascarenhas VV, Caetano A. Imaging the young adult hip in the future. Ann Joint 2018;3:47.